Physiological Partial Aldosterone Resistance in Human Newborns Running Title: Aldosterone resistance at birth
نویسندگان
چکیده
1Inserm, U693, Le Kremlin-Bicêtre, F-94276, France; 2Faculté de Médecine Paris-Sud, UMR-S693, Univ Paris-Sud 11, Le Kremlin-Bicêtre, F94276, France; 3Service de Génétique Moléculaire, Pharmacogénétique et Hormonologie, Hôpital de Bicêtre, Assistance Publique-Hôpitaux de Paris, Le Kremlin Bicêtre, F-94275, France ; 4Service de Pédiatrie et Réanimation Néonatales, Hôpital Antoine Béclère, Assistance Publique-Hôpitaux de Paris, Clamart, F-92141, France; 5Service de Biochimie, Clamart, Hôpital Antoine Béclère, Assistance Publique-Hôpitaux de Paris, , F-92141, France; 6Service de Biochimie,Assistance Publique-Hôpitaux de Paris, Hôpital de Bicêtre, Le Kremlin Bicêtre, F-94275, France; 7Service d‘Endocrinologie et Maladies de la Reproduction, Hôpital de Bicêtre, Assistance Publique-Hôpitaux de Paris, Le Kremlin Bicêtre, F-94275, France.
منابع مشابه
Low renal mineralocorticoid receptor expression at birth contributes to partial aldosterone resistance in neonates.
The human neonatal period is characterized by renal immaturity with impaired capacity to regulate water and sodium homeostasis, resembling partial aldosterone resistance. Because aldosterone effects are mediated by the mineralocorticoid receptor (MR), we postulated that this hormonal unresponsiveness could be related to low MR expression in the distal nephron. We measured aldosterone and renin ...
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BACKGROUND Low birth weight is associated with an increased risk of cardiovascular events in later life. Insulin resistance is a key finding in adult patients with cardiovascular diseases. The neonatal phenotype of an individual with insulin resistance might be low birth weight, as insulin influences fetal growth. The renin-angiotensin-aldosterone system has been associated with cardiovascular ...
متن کاملWater Balance and ‘Salt Wasting’ in the First Year of Life: The Role of Aldosterone-Signaling Defects
In newborns and infants, dehydration and salt wasting represent a relatively common cause of admission to hospital and may result in life-threatening complications. Kidneys are responsible for electrolyte homoeostasis, but neonatal kidneys show low glomerular filtration rate and immaturity of the distal nephron, leading to reduced ability to concentrate urine. High extrarenal fluid losses often...
متن کاملWater Balance and ‘Salt Wasting’ in the First Year of Life: The Role of Aldosterone-Signaling Defects
In newborns and infants, dehydration and salt wasting represent a relatively common cause of admission to hospital and may result in life-threatening complications. Kidneys are responsible for electrolyte homoeostasis, but neonatal kidneys show low glomerular filtration rate and immaturity of the distal nephron, leading to reduced ability to concentrate urine. High extrarenal fluid losses often...
متن کاملWater Balance and 'Salt Wasting' in the First Year of Life: The Role of Aldosterone-Signaling Defects.
In newborns and infants, dehydration and salt wasting represent a relatively common cause of admission to hospital and may result in life-threatening complications. Kidneys are responsible for electrolyte homoeostasis, but neonatal kidneys show low glomerular filtration rate and immaturity of the distal nephron, leading to reduced ability to concentrate urine. High extrarenal fluid losses often...
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